Systems biology of unfolded protein response in recombinant CHO cells
نویسندگان
چکیده
Background Productivity of recombinant therapeutics is a coordinated effort of multiple pathways in the cell [1]. The protein processing pathway in endoplasmic reticulum has been the target of many cell engineering studies but with mixed results [2]. We have observed the induction of UPR genes in recombinant CHO cells (data not shown). In this work, we attempt to increase their productivity further by inducing ER stress using a known UPR inducer.
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